n estimated 1-3% of cases of stomach cancer are caused by inherited syndromes. Hereditary diffuse gastric cancer (HDGC)
is an inherited cancer syndrome that leads to an increased risk for
both diffuse gastric cancer and lobular breast cancer. Patients who
inherit the genetic mutation for HDGC are at high risk for developing
stomach cancer at a young age.
In 1964, stomach cancer was noted in a Maori tribal family in New Zealand, following an autosomal dominant pattern of inheritance. CDH1 gene mutations were first described in patients from three Maori families in 1998. At this time, the International Gastric Cancer Linkage Consortium (IGCLC) was formed, and the name “Hereditary Diffuse Gastric Cancer” was introduced. Families with multiple cases of diffuse gastric cancer, lobular breast cancer, or both may be affected by hereditary diffuse gastric cancer syndrome.
http://www.nostomachforcancer.org/about/hereditary-diffuse-gastric-cancer?gclid=CMmz1LTEocoCFQ8DvAodm3YO6w
In 1964, stomach cancer was noted in a Maori tribal family in New Zealand, following an autosomal dominant pattern of inheritance. CDH1 gene mutations were first described in patients from three Maori families in 1998. At this time, the International Gastric Cancer Linkage Consortium (IGCLC) was formed, and the name “Hereditary Diffuse Gastric Cancer” was introduced. Families with multiple cases of diffuse gastric cancer, lobular breast cancer, or both may be affected by hereditary diffuse gastric cancer syndrome.
http://www.nostomachforcancer.org/about/hereditary-diffuse-gastric-cancer?gclid=CMmz1LTEocoCFQ8DvAodm3YO6w